Brand Name(s): Talvey®

Why is this medicine prescribed?

Talquetamab-tgvs is used to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or that did not respond to at least 4 other treatments. Talquetamab-tgvs is in a class of medications called bispecific T-cell engager antibodies. It works by killing cancer cells.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Talquetamab-tgvs comes as a solution (liquid) to be given subcutaneously (under the skin) by a doctor or a nurse at a healthcare facility. It is usually given on days 1, 4 and 7 then weekly thereafter or on days 1, 4, 7 and 10 and then every 2 weeks thereafter. Your doctor will probably start you on a low dose of talquetamab-tgvs and then gradually increase your dose to make sure you tolerate the medication.

Your doctor may delay or stop your treatment with talquetamab-tgvs injection, or treat you with additional medications, depending on your response to the medication and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

What special precautions should I follow?

Before receiving talquetamab-tgvs,

  • tell your doctor and pharmacist if you are allergic to talquetamab-tgvs, any other medications, or any of the ingredients in talquetamab-tgvs injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have an infection or if you have or have ever had low blood cell counts (leukopenia, neutropenia, anemia) or liver disease.
  • tell your doctor if you are pregnant or plan to become pregnant. You must have a pregnancy test before you start treatment with talquetamab-tgvs injection. You should use birth control to prevent pregnancy during your treatment with talquetamab-tgvs injection and for 3 months after your final dose. Talk to your doctor about birth control methods that you can use. If you become pregnant while receiving talquetamab-tgvs injection, call your doctor. Talquetamab-tgvs injection may harm the fetus.
  • you should know that talquetamab-tgvs may make you dizzy or cause confusion. Do not drive a car or operate machinery until you know how this medication affects you.
  • tell your doctor if you are breastfeeding. Do not breastfeed during your treatment and for 3 months after your final dose.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medicine cause?

Talquetamab-tgvs may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • fever
  • fatigue
  • chills
  • pain
  • swelling
  • nausea
  • constipation or diarrhea
  • nail discoloration
  • dry skin
  • muscle and bone pain
  • decreased appetite

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • fever, chills, weakness, cough, shortness of breath, or sore throat
  • dry mouth, difficulty swallowing, altered or loss of taste, or sores in the mouth
  • rash or redness of skin, dry skin or itching
  • feeling of racing heart
  • yellowing of skin or whites of eyes, dark urine or lower abdominal pain

Talquetamab-tgvs may cause weight loss. Talk to your doctor about the risks of taking this medication.

Talquetamab-tgvs may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( http://www.fda.gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to talquetamab-tgvs. If you miss a scheduled infusion for talquetamab-tgvs, you may have to start over with the first cycle dose.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

subscribe section background