Cholecalciferol (Vitamin D <sub>3</sub> )

pronounced as (koe" le kal sif' er ol)

Brand Name(s): Fosamax® Plus D (as a combination product containing alendronate, cholecalciferol), Tri-Vi-Sol® (as a combination product containing Vitamin A, Vitamin C, Vitamin D), Viactiv® Calcium Plus Vitamin D (as a combination product containing calcium, vitamin D)

Why is this medicine prescribed?

Cholecalciferol (vitamin D 3

) is used as a dietary supplement when the amount of vitamin D in the diet is not enough. People most at risk for vitamin D deficiency are older adults, breastfed infants, people with dark skin, obese people, and those with limited sun exposure, or gastrointestinal disease (GI; affecting the stomach or intestines) such as Crohn's disease or celiac disease. Cholecalciferol (vitamin D 3

) is also used along with calcium to prevent and treat bone diseases such as rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and osteoporosis (a condition in which the bones become thin and weak and break easily). Cholecalciferol (vitamin D 3 ) is in a class of medications called vitamin D analogs. Cholecalciferol is needed by the body for healthy bones, muscles, nerves, and to support the immune system. It works by helping the body to use more of the calcium found in foods or supplements.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Cholecalciferol (vitamin D 3 ) comes as a capsule, gel capsule, chewable gel (gummy), tablet, and liquid drops to take by mouth. It is usually taken once or twice daily depending on the preparation, your age, and your medical condition(s). Cholecalciferol is available without a prescription, but your doctor may prescribe cholecalciferol to treat certain conditions. Check with your doctor or pharmacist before taking a cholecalciferol (vitamin D) supplement. Take cholecalciferol at around the same time every day. Follow the directions on your product label or doctor's instructions carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cholecalciferol exactly as directed. Do not take more or less of it or take it more often than recommended by your doctor.

Cholecalciferol liquid drops may be added to your child's food or drink.

Cholecalciferol supplements are available alone and in combination with vitamins, and in combination with medications.

What special precautions should I follow?

Before taking cholecalciferol,

  • tell your doctor and pharmacist if you are allergic to cholecalciferol, any other medications, or any of the ingredients in cholecalciferol products. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: calcium supplements, carbamazepine (Equetro, Teril, others), cholestyramine (Prevalite), multivitamins, orlistat (Alli, Xenical), phenobarbital, phenytoin (Dilantin), prednisone (Rayos), thiazide diuretics (''water pills''), or other cholecalciferol (vitamin D) supplements and fortified foods. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in the blood]), kidney disease, or have high blood levels of calcium.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking cholecalciferol (vitamin D 3 ), call your doctor.

What special dietary instructions should I follow?

When cholecalciferol (vitamin D 3 ) is used to treat and prevent bone diseases, you should eat and drink of foods and drinks that are rich in calcium. If you find it difficult to eat enough calcium-rich foods, tell your doctor. In that case, your doctor can prescribe or recommend a calcium supplement.

What should I do if I forget to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What should I do in case of overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • loss of appetite
  • weight loss
  • nausea
  • vomiting
  • constipation
  • weakness

What side effects can this medicine cause?

Cholecalciferol (vitamin D 3 ) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • loss of appetite
  • weight loss
  • nausea
  • vomiting
  • constipation

Cholecalciferol (vitamin D 3 ) may cause other side effects. Call your doctor if you have any unusual problems while taking this vitamin.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this vitamin in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ) for more information if you do not have access to a take-back program.

What other information should I know?

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about cholecalciferol.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

subscribe section background