Why is this medicine prescribed?
Ranolazine is used alone or with other medications to treat chronic angina (ongoing chest pain or pressure that is felt when the heart does not get enough oxygen). Ranolazine is in a class of medications called anti-anginals. The exact way that ranolazine works is not known at this time.
Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Ranolazine comes as an extended-release (long-acting) tablet to take by mouth. It is usually taken with or without food twice daily. Take ranolazine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ranolazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole; do not break, chew, or crush them.
Your doctor will probably start you on a low dose of ranolazine and gradually increase your dose.
Do not take ranolazine to treat a sudden attack of angina. Your doctor will tell you what you should do if you experience an attack of angina. Make sure that you understand these directions.
Ranolazine may help control your condition but will not cure it. Continue to take ranolazine even if you feel well. Do not stop taking ranolazine without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
What special precautions should I follow?
Before taking ranolazine,
- tell your doctor and pharmacist if you are allergic to ranolazine, any other medications, or any of the ingredients in ranolazine extended-release tablets. Ask your pharmacist for a list of the ingredients.
- some medications should not be taken with ranolazine. Other medications may cause dosing changes or extra monitoring when taken with ranolazine. Make sure you have discussed any medications you are currently taking or plan to take before starting ranolazine with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking ranolazine, please get the advice of your doctor or pharmacist.
- the following herbal product may interact with ranolazine: St. John's wort. Be sure to let your doctor and pharmacist know that you are taking this medication before you start taking ranolazine. Do not start this medication while taking ranolazine without discussing with your healthcare provider.
- tell your doctor if you have or have ever had liver disease. Your doctor may tell you that you should not take ranolazine.
- tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause fainting or irregular heartbeat) or a fast, slow, or irregular heartbeat. Also tell your doctor if you have or have ever had an abnormal electrocardiogram (ECG: a test that records the electrical activity of the heart), low levels of potassium in the blood, or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ranolazine, call your doctor.
- you should know that ranolazine may make you dizzy and lightheaded. Do not drive a car, operate machinery, or participate in activities requiring mental alertness and coordination until you know how this medication affects you.
What special dietary instructions should I follow?
Do not drink grapefruit juice or eat grapefruit products while taking this medication.
What should I do if I forget to take a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What should I do in case of overdose?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
- nausea
- vomiting
- dizziness
- confusion
- double vision
- pain, burning, numbness, or tingling in any part of the body
- fainting
- uncontrollable shaking of a part of the body
- difficulty speaking
- seeing things or hearing voices that do not exist
What side effects can this medicine cause?
Ranolazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- constipation
- headache
- dizziness
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- fast, pounding, or irregular heartbeat
- difficulty breathing
- fainting
Ranolazine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p ) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.