Why is this medicine prescribed?
Brensocatib is used to treat non-cystic fibrosis bronchiectasis (NCFB; a lung condition caused by inflamed and damaged airways). Brensocatib is in a class of medications called dipeptidyl peptidase 1 (DPP1) inhibitors. It works by decreasing inflammation and improving lung function.
Are there other uses for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Brensocatib comes as a tablet to take by mouth. Take once a day with or without food. Take brensocatib at around the same time every day.
Take brensocatib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
What special precautions should I follow?
Before taking brensocatib,
- tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you have or have ever had problems with your teeth, mouth, or gums; skin problems, high blood pressure, or liver problems.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking brensocatib, call your doctor.
- do not have any vaccinations without talking to your doctor.
- Brensocatib may cause serious problems with your teeth and gums. Brush your teeth and clean your mouth carefully while you are taking brensocatib. See a dentist regularly during your treatment. Call your dentist immediately if you have a toothache, mouth pain, or any other problems with your teeth or gums.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking brensocatib.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget to take a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What should I do in case of overdose?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What side effects can this medicine cause?
Brensocatib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- cough, runny nose, or sore throat
- headache
- hair loss
Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:
- rash; dry, thickened, or peeling skin; or dry or chapped lips
Brensocatib may increase the risk of developing skin cancer. Talk to your doctor about the risks of taking this medication.
Brensocatib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( https://www.fda.gov/Safety/MedWatch ) or by phone ( 1-800-332-1088).What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.