Eravacycline Injection

pronounced as (er" a va sye' kleen)

Brand Name(s): Xerava®
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Why is this medicine prescribed?

Eravacycline injection used to treat infections of the abdomen (stomach area). Eravacycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infection.

Antibiotics such as eravacycline injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Eravacycline comes as a powder to be mixed with fluid and injected into a vein. It is given over a period of 60 minutes once every 12 hours for 4 to 14 days. The length of treatment is will depend on your condition and how your body responds to the medication.

You may receive eravacycline injection in a hospital or you may use the medication at home. If you will be using eravacycline injection at home, your healthcare provider will show you how to infuse the medication. Ask your healthcare provider what to do if you have any problems infusing eravacycline injection.

You should begin to feel better during the first few days of treatment with eravacycline. If your symptoms do not improve or get worse, call your doctor.

Use eravacycline until you finish the prescription, even if you feel better. If you stop using eravacycline too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What special precautions should I follow?

Before receiving eravacycline injection,

  • tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving eravacycline injection. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had liver disease.
  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while receiving eravacycline injection, call your doctor. Eravacycline may harm the fetus.
  • tell your doctor if you are breastfeeding. You should not breastfeed during your treatment and for 4 days after your last dose.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Eravacycline injection may make your skin sensitive to sunlight.
  • you should know that when eravacycline injection is used during pregnancy or in babies and children under 8 years old, it can permanently staine teeth and affect bone growth. Eravacycline injection should not be used in children under age 8 unless your doctor decides it is needed.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do in case of overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What side effects can this medicine cause?

Eravacycline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea, vomiting, diarrhea
  • dizziness
  • pain, redness, or swelling near the place where eravacycline was injected

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • wound healing problems
  • skin redness or purple color; itching, burning, blistering, or peeling skin
  • rash, hives, itching; tingling or swelling of the face, neck, throat, tongue, lips, or eyes; difficulty breathing or swallowing itching
  • headache; blurred vision; seeing double; or loss of vision
  • ongoing pain that begins in the stomach area but may spread to the back
  • sore throat, fever, chills, and other signs of new or worsening infection

Eravacycline injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( https://www.fda.gov/Safety/MedWatch ) or by phone ( 1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the refrigerator, closed tightly, and throw away any unused reconstituted medication after 8 days.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach https://www.upandaway.org Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to eravacycline injection.

Do not let anyone else take your medication. If you still have symptoms of infection after you finish eravacycline injection, call your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS ® Patient Medication Information™. © Copyright, 2026. The American Society of Health-System Pharmacists ® , 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: May 15, 2026.