Delafloxacin Injection

Delafloxacin injection increases the risk of tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. It can happen at any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone, or prednisone. If you experience any of the following symptoms of tendinitis, stop using delafloxacin injection, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop using delafloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or cannot move or put weight on an affected area.

Delafloxacin injection may cause changes in sensation and nerve damage that can occur soon after you begin using it and may not go away even after you stop using delafloxacin injection. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop using delafloxacin injection and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold.

Delafloxacin injection may cause serious brain or nervous system side effects. This can occur after the first dose of delafloxacin injection. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop using delafloxacin injection and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist) or delusions (strange thoughts or beliefs that have no basis in reality); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, or confused; memory problems; or other changes in your mood or behavior.

Delafloxacin injection may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to use delafloxacin injection. If you have myasthenia gravis and your doctor tells you that you should use delafloxacin injection, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of using delafloxacin injection.

Uses
How to Use
Precautions
Side Effects
Storage/Disposal
More Information

Why is this medicine prescribed?

Delafloxacin injection is used to treat skin infections and pneumonia (infection of the lungs) caused by bacteria. Delafloxacin is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.

Are there other uses for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Delafloxacin injection comes as a powder to mixed with liquid and given intravenously (into a vein). It is given over a period of 60 minutes once every 12 hours.

You may receive delafloxacin injection in a hospital, or you may use the medication at home. If you will be using delafloxacin injection at home, your healthcare provider will show you how to infuse the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems infusing delafloxacin injection.

You should begin to feel better during the first few days of treatment with delafloxacin injection. If your symptoms do not improve or get worse, call your doctor.

Use delafloxacin injection until you finish the prescription, even if you feel better. Do not stop using delafloxacin injection without talking to your doctor unless you experience certain serious side effects listed in the IMPORTANT WARNING or SIDE EFFECTS sections. If you stop using delafloxacin injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What special precautions should I follow?

Before using delafloxacin injection,

tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving delafloxacin injection. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had an aortic aneurysm (swelling of the large artery that carries blood from the heart to the body), high blood pressure, peripheral vascular disease (poor blood flow through blood vessels), Marfan syndrome (a genetic condition that can affect the heart, eyes, blood vessels and bones), Ehlers-Danlos syndrome (a genetic condition that can affect skin, joints, or blood vessels), diabetes, or problems with low blood sugar.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using delafloxacin injection, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget to take a dose?

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What should I do in case of overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help . If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What side effects can this medicine cause?

Delafloxacin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

nausea, vomiting, diarrhea
headache
irritation, pain, tenderness, redness, warmth, or swelling at the injection spot

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, stop using delafloxacin injection and call your doctor immediately or get emergency medical treatment:

severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
rash, itching, hives, shortness of breath, tingling or swelling of the face or throat, or fainting
extreme thirst or hunger; pale skin; feeling shaky or trembling; fast or fluttering heartbeat; sweating; frequent urination; trembling; blurred vision; or unusual anxiety
sudden pain in the chest, stomach, or back

Delafloxacin injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( https://www.fda.gov/Safety/MedWatch ) or by phone ( 1-800-332-1088).

What should I know about storage and disposal of this medication?

Your healthcare provider will tell you how to store your medication. Store your medication only as directed. Make sure you understand how to store your medication properly.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach https://www.upandaway.org Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://www.fda.gov/drugs/safe-disposal-medicines/disposal-unused-medicines-what-you-should-know for more information.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to delafloxacin injection. If you have diabetes, your doctor may ask you to check your blood sugar more often while using delafloxacin.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the delafloxacin injection, call your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS ^® Patient Medication Information™. © Copyright, 2026. The American Society of Health-System Pharmacists ^® , 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: August 15, 2026.