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Fremanezumab-vfrm Injection

(free" ma nez' ue mab)

Brand Name(s): Ajovy®

WHY is this medicine prescribed?

Fremanezumab-vfrm injection is used to help prevent migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Fremanezumab-vfrm injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes migraine headaches.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Fremanezumab-vfrm injection comes as a solution (liquid) in a prefilled syringe and as a prefilled autoinjector to be injected subcutaneously (under the skin). It is usually given either once a month (as 1 injection) or once every 3 months (as 3 separate injections given one right after the other). Use fremanezumab-vfrm injection at around the same day every 1 or 3 month(s), depending on your dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use fremanezumab-vfrm injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

You may be able to inject the medication yourself at home or have a friend or relative perform the injections. Ask your doctor to show you or the person who will be performing the injections how to inject the medication.

Fremanezumab-vfrm injection comes as a prefilled syringe and a prefilled autoinjector. Allow the syringe and autoinjector to warm to room temperature for 30 minutes away from direct sunlight before you inject the medication. Do not try to warm the medication by heating it in a microwave, placing it in hot water, or through any other method. Use each syringe or autoinjector only once and inject all the solution in the syringe or autoinjector. Dispose of used syringes or the autoinjector in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

Inject fremanezumab-vfrm into thigh, upper arm, or stomach area. Do not inject into an area where the skin is tender, thick, bruised, red, scaly, hard, or has scars or stretch marks.

Always look at fremanezumab-vfrm before you inject it. It should be clear and colorless. Do not use fremanezumab-vfrm injection, if it is colored, cloudy, or contains flakes or solid particles. Do not shake it.

If your doctor tells you to inject three separate injections one after another, use a different syringe or autoinjector for each injection. If you use the same body site (upper arm, thigh, or stomach) for the separate injections, make sure that each injection it is not at the exact same spot you used for the other injections.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What SPECIAL PRECAUTIONS should I follow?

Before using fremanezumab-vfrm injection,

  • tell your doctor and pharmacist if you are allergic to fremanezumab-vfrm, any other medications, or any of the ingredients in fremanezumab-vfrm injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using fremanezumab-vfrm injection, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

If you forget to inject your dose at the regular time, inject it as soon as you remember. Then continue your dosing schedule from the date of your last dose.

What SIDE EFFECTS can this medicine cause?

Fremanezumab-vfrm injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • injection site pain, swelling, or redness

Some side effects can be serious and may occur up to 1 month after you receive your injection. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • swelling of your face, mouth, tongue, or throat
  • difficulty breathing
  • rash
  • itching
  • hives

Fremanezumab-vfrm injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in to protect from light, tightly closed, and out of reach of children. Store it in the refrigerator, but do not freeze it. After removal from the refrigerator, the medication may be kept in the original carton at room temperature for up to 24 hours. Dispose of fremanezumab-vfrm injection if it has been left at room temperature for more than 24 hours.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists® represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists® makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists® does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

Pronunciation Guide for Drug Names is used with permission. © 2009. The United States Pharmacopeial Convention. All Rights Reserved.

AHFS® Patient Medication Information™. © Copyright, 2020. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: May 15, 2020.