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Meropenem and Vaborbactam Injection

(mer'' oh pen' em)(va'' bor bak' tam)

Brand Name(s): Vabomere®

WHY is this medicine prescribed?

Meropenem and vaborbactam injection is used to treat serious urinary tract infections, including kidney infections, that are caused by bacteria. Meropenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Vaborbactam is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying meropenem.

Antibiotics such as meropenem and vaborbactam injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Meropenem and vaborbactam injection comes as a powder to be mixed with liquid and injected intravenously (into a vein). It is infused (injected slowly) intravenously over a period of 3 hours every 8 hours for up to 14 days. The length of treatment depends on your general health and how well you respond to the medication. Your doctor will tell you how long to use meropenem and vaborbactam injection. After your condition improves, your doctor may switch you to another antibiotic that you can take by mouth to complete your treatment.

You may receive meropenem and vaborbactam injection in a hospital, or you may administer the medication at home. If you will be receiving meropenem and vaborbactam injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions and ask your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with meropenem and vaborbactam injection. If your symptoms do not improve or if they get worse, call your doctor.

Use meropenem and vaborbactam injection until you finish the prescription, even if you feel better. If you stop using meropenem and vaborbactam injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What SPECIAL PRECAUTIONS should I follow?

Before using meropenem and vaborbactam injection,

  • tell your doctor and pharmacist if you are allergic to meropenem, vaborbactam, other carbapenem antibiotics such as doripenem (Doribax), ertapenem (Invanz), or imipenem and cilastatin (Primaxin); cephalosporin antibiotics such as cefaclor, cefadroxil, cefuroxime (Ceftin, Zinacef), and cephalexin (Keflex); other beta-lactam antibiotics such as penicillin or amoxicillin (Amoxil, Trimox, Wymox); any other medications, or any of the ingredients in meropenem and vaborbactam injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention probenecid (Probalan, in Col-Probenecid) and valproic acid (Depakene, Depakote, Depacon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had seizures, brain lesions, or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving meropenem and vaborbactam injection, call your doctor.
  • you should know that meropenem and vaborbactam injection may affect mental alertness or motor skills. Do not drive a car or operate machinery until you know how this medication affects you.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Meropenem and vaborbactam injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • diarrhea
  • nausea
  • redness, pain, or swelling at the injection site
  • burning or tingling in the hands or feet
  • confusion

Some side effects can be serious. If you experience any of these symptoms, stop using meropenem and vaborbactam injection and call your doctor immediately or get emergency medical treatment:

  • seizures
  • hives
  • itching
  • rash
  • flushing
  • swelling of the face, throat, tongue, lips, and eyes
  • difficulty swallowing or breathing
  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • a return of fever or other signs of infection

Meropenem and vaborbactam injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to meropenem and vaborbactam injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists® represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists® makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists® does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

Pronunciation Guide for Drug Names is used with permission. © 2009. The United States Pharmacopeial Convention. All Rights Reserved.

AHFS® Patient Medication Information™. © Copyright, 2020. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: November 15, 2017.