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Daptomycin Injection

(dap'' toe mye' sin)

Brand Name(s): Cubicin®, Cubicin RF®; also available generically

WHY is this medicine prescribed?

Daptomycin injection is used to treat certain blood infections or serious skin infections caused by bacteria in adults and children 1 year of age and older. Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria.

Antibiotics such as daptomycin injection will not work for treating colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Daptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on the type of infection being treated and your response to daptomycin treatment. You may receive daptomycin injection in a hospital or you may administer the medication at home. If you will be using daptomycin injection at home, your healthcare provider will show you how to infuse the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems infusing daptomycin injection.

You should begin to feel better during the first few days of treatment with daptomycin injection. If your symptoms do not improve or if they get worse, call your doctor.

Use daptomycin injection until you finish the prescription, even if you feel better. If you stop using daptomycin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What SPECIAL PRECAUTIONS should I follow?

Before using daptomycin injection,

  • tell your doctor and pharmacist if you are allergic to daptomycin, any other medications, or any of the ingredients in daptomycin injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor, in Vytorin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using daptomycin injection, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Daptomycin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • stomach pain
  • difficulty falling asleep or staying asleep
  • headache
  • dizziness
  • increased sweating
  • redness, pain, or swelling at the injection site
  • unusual weight gain
  • sore throat

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • hives
  • rash
  • itching
  • blisters or peeling of skin
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, and eyes
  • shortness of breath
  • chest pain
  • cough
  • new or worsening fever, sore throat, chills, increased urge to urinate, burning sensation when urinating, or other signs of infection
  • severe diarrhea with watery or bloody stools (up to 2 months after your treatment)
  • muscle pain or weakness, especially in the forearms and lower legs
  • dark or cola-colored urine
  • pain, burning, numbness, or tingling in the hands or feet

Daptomycin injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to daptomycin injection.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are using daptomycin injection.

Do not let anyone else use your medication. If you still have symptoms of infection after you finish daptomycin injection, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists® represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists® makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists® does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

Pronunciation Guide for Drug Names is used with permission. © 2009. The United States Pharmacopeial Convention. All Rights Reserved.

AHFS® Patient Medication Information™. © Copyright, 2020. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: December 15, 2019.